منابع مشابه
Bone microdamage and cell apoptosis.
Accumulation of microdamage in bone leads to the reduced strength of our skeleton. In health, bone adapts to the prevailing mechanical needs of the organism and is also capable of self-repair, sensing, removing and replacing damaged or mechanically insufficient volumes of bone. In disease and old age these characteristics are reduced. In order to undertake both of the processes of functional ad...
متن کاملFluorescence imaging of bone cracks (microdamage) using visibly emitting 1,8-naphthalimide-based PET sensors
The ability of two 4-amino-1,8-naphthalimide (1 and 2) and anthracene (3) based photoinduced electron transfer (PET) sensors, previously developed in our laboratory, to function as selective imaging agents for exposed Ca(II) in bone cracks, using fluorescence microscopy imaging is described. While the emission from 3 is masked by the autofluorescence arising from the (bovine) bone matrix, both ...
متن کاملDetection of trabecular bone microdamage by micro-computed tomography.
Microdamage is an important component of bone quality and affects bone remodeling. Improved techniques to assess microdamage without the need for histological sectioning would provide insight into the role of microdamage in trabecular bone strength by allowing the spatial distribution of damage within the trabecular microstructure to be measured. Nineteen cylindrical trabecular bone specimens w...
متن کاملContrast Agents for Micro-Computed Tomography of Microdamage in Bone
Accumulation of microdamage during fatigue can lead to increased fracture susceptibilityin bone. Current techniques for imaging microdamage in bone are inherently destructiveand two-dimensional. Therefore, the objective of this study was to image the accumulationof fatigue microdamage in cortical bone using micro-computed tomography (micro-CT)with a barium sulfate (BaSO4) contra...
متن کاملMicroarchitecture Influences Microdamage Accumulation in Human Vertebral Trabecular Bone
It has been suggested that accumulation of microdamage with age contributes to skeletal fragility. However, data on the age-related increase in microdamage and the association between microdamage and trabecular microarchitecture in human vertebral cancellous bone are limited. We quantified microdamage in cancellous bone from human lumbar (L(2)) vertebral bodies obtained from 23 donors 54-93 yr ...
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ژورنال
عنوان ژورنال: Connective Tissue Research
سال: 2015
ISSN: 0300-8207,1607-8438
DOI: 10.3109/03008207.2015.1008133